Phenylhydrazine haematotoxicity

Phenylhydrazine haematotoxicity

Phenylhydrazine (PHZ) and its derivatives were first given a medical application at the end of the 19th century but with very little benefit. However, this compound seems to be very useful in models studying mechanisms of haemolytic anaemia. Phenylhydrazine induces a reactive oxygen species formation, peroxidation of lipids and oxidative degradation of spectrin in the membrane skeleton. PHZ-ind...

NSRL for Phenylhydrazine and Phenylhydrazine Hydrochloride

The cancer potencies of phenylhydrazine and phenylhydrazine hydrochloride were estimated from dose-response data from three data sets: lung tumors among male and female mice (combined) exposed orally to phenylhydrazine hydrochloride (Clayson et al., 1966) and blood vessel tumors among male and female mice exposed orally to phenylhydrazine hydrochloride (Toth and Shimizu, 1976). Studies of pheny...

Plasma and erythrocyte enzymes in phenylhydrazine anemia.

SEVERAL YEARS AGO LaDue (2) made the iiiteresting observation that soon after myocardial infarction the plasma glutamic oxalacetie tramisammase is increased, reaches a peak within a few days, and then returns to normal. This observation stimulated a new area of clinical interest ill diseases related to infarction and necrosis as manifested ill plasma enzymes changes. The source of this increase...

Cardiac hypertrophy in rats with phenylhydrazine anemia.

THIS investigation was undertaken for the purpose of studying the effect of anemia upon the hearts of rats, of determining whether cardiac hypertrophy occurs, and, if so, of studying the mechanism of hypertrophy. In spite of the widespread belief that cardiac hypertrophy does occur with anemia, Stembridge and Rigdon have indicated the lack of evidence to support many of the reported cases. Thei...

Positive direct Coombs test induced by phenylhydrazine.